Ophthalmic Biophysics And Mechanobiology Laboratory

Finite Element Modeling Of The Cornea And Penetrating Keratoplasty

Investigators: Ashutosh Richhariya, Geunyoung Yoon, R. Peruchhio

Support:Hyderabad Eye Research Foundation

Penetrating Keratoplasty is a very complicated procedure and with a lot of variability in visual performance as the outcome. To control the variability in the restored vision it is necessary to understand the sources, which contributes to this variability and find measures to control them so as to achieve best possible visual rehabilitation after the surgery.

An engineering modeling and analysis tool is used to understand the role of physiological stresses, suturing and anisotropy of the cornea and the effect of these parameters on optical quality of the cornea.

The model is being used to study the variability and after compilation of the results will be communicated through the peer-reviewed journal and conference presentations.

Automated Algorithm For Blood Vessel Count And Area Measurement In 2-D Choroidal Scan Images

Investigators: Ashutosh Richhariya, Sumohana Chanappaya, Jay Chhablani

Support: Hyderabad Eye Research Foundation

We present an automated algorithm for the detection of blood vessels in 2-D choroidal scan images followed by a measurement of the area of the vessels. The objective is to identify vessel parameters in the choroidalstroma that are affected by various abnormalities. The algorithm is divided into five stages. In the first stage, the image is denoised to remove sensor noise and facilitate further processing. In the second stage, the image is segmented in order to find the region of interest. In the third stage, three different contour detection methods are applied to address different challenges in vessel contour. In the fourth stage, the outputs of the three contour detection methods are combined to achieve refined vessel contour detection. In the fifth and final stage, the area of these contours is measured. The results have been evaluated by a practicing ophthalmologist and performance of the algorithm relative to expert detection is reported.

As a first part of the study one article has been accepted for publication in IEEE transactions on Engineering in Medicine and Biology and second part of the study is going to be presented in conferences and later we intend to submit it in peer-reviewed journal.

Infra-Red Imaging System For Dry Eye And Ocular Surface Examination

Investigators: Ashutosh Richhariya, Sumohana Chanappaya, Siva Vanjari, Mukesh Taneja

Support: Hyderabad Eye Research Foundation

We are trying to build a system for ocular surface studies with a state of the art infra red imaging device. The design of it is complete and the instrument is expected to come in third week of June for initial experimentation. It is expected that the development of prototype will complete in August and from then the process of experimental data collection will start.

Three Dimensional Imaging And Reconstruction Of Facial And Orbital Region

Investigators: Ashutosh Richhariya, Soumya Jana, Milind Naik

Support: Hyderabad Eye Research Foundation

We are trying to build a system for ocular surface studies with a state of the art infra red imaging device. The design of it is complete and the instrument is expected to come in third week of June for initial experimentation. It is expected that the development of prototype will complete in August and from then the process of experimental data collection will start.

Three Dimensional Imaging And Reconstruction Of Facial And Orbital Region

Investigators: Ashutosh Richhariya, Soumya Jana, Milind Naik

Support: Hyderabad Eye Research Foundation

We are trying to build an imaging system capable of recording real time three dimensional images of the facial and orbital region of the subjects. We intend to use it for facial and orbital reconstruction. The aim is to integrate this system with a modeling tool to predict and then use as a decision support system for surgery.

Evaluation Of Image Enhancement As A Vision Rehabilitation Tool

Investigators: PremNandhini Satgunam, Cyril Sara Babukutty

Support: Hyderabad Eye Research Foundation

Patients with vision impairment (acuity between 20/60 to 20/400) are conventionally helped with magnifying devices such as telescopes. While providing magnification these devices also reduces the field of view, thus forcing the user to make several scanning eye/head movements. Such a device is not a practical solution for vision impaired children to use in their classrooms. In this project, we investigate if image enhancement technology can be used with computers to help in visual performance of vision impaired patients. Visual performance will be studied through a visual search experiment. Appropriate low vision devices can then be developed based on the study outcome.

Validation Of Mechanized Tangent Screen Kinetic Perimeter For Mapping Visual Fields

Investigators: PremNandhini Satgunam, Ashutosh Richhariya

Support: Hyderabad Eye Research Foundation

Visual field defects are common in leading cause of blindness such as glaucoma and in other neurological conditions such as stroke, pituitary gland tumor etc. While static perimetry (testing visual fields) may be appropriate for glaucoma, kinetic perimeter is more suited to study visual field defects in neurological conditions and also on patients with severe vision impairment. This project aims to develop an indigenous kinetic perimeter that can better assess the functional visual fields.

Critical Brain Changes – Development And Plasticity Of Multisensory Functions To Study The Principles Of Age Dependent Learning Plasticity In Humans

Investigators: Ramesh Kekunnaya, Bhamy H. Shenoy, Pia Ley, Davide Bottari, Brigitte Röder

Support: European Research Council (ERC) Grant

The fundamental aim of the above project is to determine the developmental trajectory of multisensory functions, including possible sensitive phases. On the one hand, this implies the study of multisensory functions in infants and typically developing children of different ages, adopting a cross-sectional approach. On the other hand, to compare healthy controls to special populations that experienced altered developmental conditions, such as sensory loss (e.g. blindness, deafness). In addition, to investigate how multisensory functions develop in blind and deaf individuals who regained access to the deprived sensory modality at different ages through reafferentation (e.g. cochlear implantation in the deaf; cataract surgery in individuals with cataract). Combining these research strategies will allow evaluating the impact of uni- and multisensory experience of the functional development and plasticity of neuro-sensory functions. Thus, the project will provide insight into major principles of age dependent learning plasticity in humans.

Footnote

  1. University of Rochester, USA
  2. IIT,Hyderabad
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